For instance, dioxins and polyaromatic hydrocarbons activate AhR via environmental ligands, leading to the production of reactive oxygen species and oxidative stress as well as promoting the generation of proinflammatory cytokines, including CYP1A1-mediated interleukin (IL)1, IL6, and IL8, thereby contributing to the pathogenesis of AD, psoriasis, skin cancer, and aging [4,5,6]. The gene discussed is CYP1A1; the disease is Alzheimer disease.