WNK2 and Alzheimer disease: For instance, bisdemethoxycurcumin, a curcumin derivative, was found to significantly improve symptoms in 2,4-dinitrochlorobenzene (DNCB)-induced AD in mice by inhibiting inflammatory pathways such as mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NFκB), which are crucial in the pathogenesis of AD [52].