In rats with chronic immobilization stress, BP was found to suppress neuroinflammation (mainly evaluated by TNF-α and IL-1β levels in the hippocampus) and concomitant oxidative events and to enhance corrective mechanisms such as brain-derived neurotrophic factor (BDNF) levels and antioxidant defense, in addition to the reduction of the anxiety-like behavior [306]. This evidence concerns the gene BDNF and Anxiety.