Choi et al. conjugated photosensitizer verteporfin (VPF) and indolamine 2,3-dioxygenase (IDO) degradable proteolysis targeting chimera (PROTAC) through tumor-overexpressed enzyme cathepsin B cleavable linker peptide (KRR) to form light-triggered PROTAC nanoassemblies (LPNs) (Figure 2A) [83]. This evidence concerns the gene IDO1 and neoplasm.