IGF1 and Hyperglycemia: The alcoholic extract of D. bulbosum ameliorated hyperglycemia and diabetic complications in STZ-induced diabetic rats by inhibiting the expression of pro-angiogenic factors, including VEGF/VEGFR2, MMP 2/9, PDGF A/B, bFGF, and insulin-like growth factor 1 (IGF-1) [27].