Moreover, the loss of PSP94, a prostatic secretory protein of 94 amino acids, acting as a tumor suppressor in advanced hormone-refractory prostate cancer, may occur in correlation with an increased expression of EZH2, via the trimethylation of histone H3K27, in the MSMB gene, which encodes for PSP94 [24]. This evidence concerns the gene MSMB and neoplasm.