Moreover, EZH2 upregulation in the cells of tumor microenvironment sustains carcinogenesis, as it promotes the production of pro-angiogenic/immunosuppressive factors by tumor-associated fibroblasts (CAF), suppresses the expression of NKG2D ligands, thus reducing the NK cytotoxic response, promotes the T reg phenotype in T lymphocytes, and alters cellular metabolism increasing the production of lactic acid through the Warburg effect [77,78,79,80]. This evidence concerns the gene EZH2 and neoplasm.