EZH1/EZH2 dual inhibitors, for example, UNC1999, which is an effective autophagy inducer, has been reported to reduce the diffuse large B-cell lymphoma cell survival [84], and Valemetostat (DS-3201, DS-3201b) is particularly efficient against adult T-cell leukemia lymphoma cells (ATL cells) [85]. This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.