EZH2 and neoplasm: Among the non-histone targets of EZH2, there is the Retinoic Acid-Related Orphan Nuclear Receptor α (RORα), considered a tumor suppressor, as its activation correlates with a reduced migratory and invasiveness of androgen-independent prostate cancer cells [31] and with a reduced canonical Wnt/b-catenin signaling in colon cancer [32].