CD40LG from platelets mediates thrombotic and inflammatory processes, contributing to inflammation associated with viral infections [34], which have a higher prevalence in Yakutia (COVID-19 in particular) [35] due to, among other factors, weakened nasal defenses (cold weather slows the ability to clear mucus from the nose, which makes it easier for viruses to enter the body). The gene discussed is CD40LG; the disease is viral infectious disease.