High IL27 levels are associated with many autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis) [42], which are statistically less common in Yakutia [35], and are also negatively correlated with HIV viral load [42], which is more common in Yakutia (and IL27 levels are lower there) [35]. Here, IL27 is linked to systemic lupus erythematosus.