Pathological angiogenesis can occur through the upregulation of specific chemokines (e.g., CXCL8 and CXCL12) that activate pro-angiogenic mediators, such as vascular the VEGF and/or recruit progenitor endothelial cells for carcinomas (EPCs), stimulating the formation of new blood vessels and cancer progression [16,86]. Here, CXCL8 is linked to cancer.