Accordingly, Pedersen et al. (2016) observed that accumulated sessions of physical exercise (i.e., chronic effect) induced low levels of hypoxia and a high expression of CCL3 and CXCL10 chemokines, which are linked to the activation of chemotaxis of immune cells, such as NK in mice [116], towards the TME, to reprogram tumor immunity. The gene discussed is CCL3; the disease is neoplasm.