Not less important, physical exercise induces shear stress in the tumor vascular wall and may modulate angiogenic factors (e.g., VECF-A, VEGF-R2, CD31) and the chemokine CCL3 in endothelial cells, which are strongly related with stimulating physiologic angiogenesis stimulation [26,36,105,129,130]. This evidence concerns the gene CCL3 and neoplasm.