ZNF469 and aortic aneurysm: A 76-year-old Caucasian American female was diagnosed by TEE during an aortic valve evaluation with an aortic aneurysm measuring 4.3–4.4 cm (Figure 1), who subsequently underwent genetic testing, which revealed a heterozygous mutation VUS of p.G1933V in ZNF469, with a GS of 109 (a dissimilar amnio acid substitution), in a position that is poorly conserved in vertebrates.