The existence of SNPs rs1800871 or rs1800872 in the interleukin IL-10 gene and rs1800470 or rs11568848 in the TGF-β1 gene down-regulates the production of these immunosuppressive cytokines, crucially contributing to the breakage of Treg-dependent immune tolerance in the lacrimal and salivary glands of patients with pSS [11,18]. Here, IL10 is linked to peeling skin syndrome.