ASB3 and lupus nephritis: ASB3 (Ankyrin Repeat And SOCS Box Containing 3) is a negative regulator of TNF receptor 2 (TNFR2)-mediated cell response to tumour-necrosis factor alpha (TNF-α) [74], shown to have a proinflammatory role in lupus nephritis and ANCA-associated glomerulonephritis, and the effectiveness of anti-TNF-α medications is being assessed in clinical trials [75].