MPO and ganglioneuroma: In animal studies, the administration of sub-nephritogenic anti-GBM antibodies enhanced the reactivity of anti-MPO antibodies against rat MPO, leading to glomerular crescent formation, neutrophil infiltration and development of NETs, as well as increased glomerular expression and serum expression of TNF-α, CXCL1, CXCL2 and CXCL8, and therefore recapitulating the human GN phenotype [116].