The most notable genetic correlations were found with the Retinoid X Receptor Beta (RXRB) gene found in a GPA cohort of Northern German patients and with [60] theRING finger protein 1 gene, which encodes one of the E3 ubiquitin-protein ligases, found to be strongly associated with GPA in ANCA-positive subjects [80]. This evidence concerns the gene UBE2E3 and granulomatosis with polyangiitis.