Additionally, we did not observe activation of innate (TNF-α and IL-6 cytokines) or adaptive immune response (neutralizing antibodies, INF-γ + CD8+ T cells) in healthy or tumor-bearing immunocompetent C57BL/6 mice injected with MB/virus complexes following ultrasound-targeted MB destruction (UTMD) [9]. The gene discussed is TNF; the disease is neoplasm.