Although EWSR1::ATF1-positive cancers are usually rare pathologies, they include histopathologically different and particularly malignant neoplasms like the two pediatric central nervous system cancers, the intracranial non-myxoid angiomatoid fibrous histiocytoma (iAFH) and the atypical central neurocytoma [18,19]. Here, ATF1 is linked to cancer.