The observation that EWSR1::ATF1-positive clear cell sarcomas show consistent melanocytic differentiation and expression of the melanocytic-specific MITF (MITF-M) transcript fueled the idea of the EWSR1::ATF1 fusion protein-mediated transactivation of the MITF promoter [112,122,123]. This evidence concerns the gene EWSR1 and clear cell sarcoma.