FOXO1 and type 1 diabetes mellitus: They showed that the forkhead box protein O1 (FoxO1—a key regulator of cellular metabolism and an early predictor of CVDs) is significantly upregulated in carotid arteries in the T1DM rat model, accompanied with adverse vascular remodeling described as increased wall thickness, a carotid medial cross-sectional area, a media-to-lumen ratio, and a decreased carotid artery lumen area.