This study also indicates that the KRAS/ROS/NLRP3/IL-1β axis is also active in AML cells, and suggests that KRAS activation leads to RCA1 activation, which, via NADPH oxidase activation and ROS generation, promote NLRP3-mediated release of innate immune cytokines. This evidence concerns the gene NLRP3 and acute myeloid leukemia.