NLRP3 and hematologic disorder: Additionally, Hamarsheh et al. [58] have demonstrated that the NLRP3 inflammasome is implicated in other hematological diseases, such as chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia, particularly through the Kirsten rat sarcoma viral oncogene homologue (KRAS)/RAC1/reactive oxygen species (ROS)/NLRP3/IL-1β axis.