APP and glioblastoma: Another notable study [100] on glioblastoma, whose incidence peaks between the ages of 65 and 75, found 11 genes (UBC, HDAC1, CTNNB1, TRIM28, CSNK2A1, RBBP4, TP53, APP, DAB1, PINK1, and RELN), five miRNAs (hsa-mir-221-3p, hsa-mir-30a-5p, hsa-mir-15a-5p, hsa-mir-130a-3p, and hsa-let-7b-5p), six metabolites (including N6-acetyl-L-lysine, cholesterol, and formate), and 15 distinct signaling pathways that are essential for the development of glioblastoma.