Major genomic contributors to the development of HF are IANK1, ANKRD13D, C5, HPCAL1, ITGA9, MMP20, MTSS1, NUP210, PTTG1IP, RAB11FIP3, TRIM69, TSPAN16, ZFP3, and ZNF146;These genes operate cardiomyocyte structure and function, actin cytoskeleton function, cytokine signaling, intercellular communication and junctions, matrix reshapement;The authors also point out the possible limitation in generalization due to the fact that the analysis was performed from the samples of individuals of mainly white European ancestry. The gene discussed is HPCAL1; the disease is hydrops fetalis.