TSPAN16 and hydrops fetalis: Major genomic contributors to the development of HF are IANK1, ANKRD13D, C5, HPCAL1, ITGA9, MMP20, MTSS1, NUP210, PTTG1IP, RAB11FIP3, TRIM69, TSPAN16, ZFP3, and ZNF146;These genes operate cardiomyocyte structure and function, actin cytoskeleton function, cytokine signaling, intercellular communication and junctions, matrix reshapement;The authors also point out the possible limitation in generalization due to the fact that the analysis was performed from the samples of individuals of mainly white European ancestry.