The effects of jacaranone involve the induction of cIAP2 degradation, leading to the disruption of the ‘NF-κB death checkpoint’ and disassembly of TNFR1 signaling complex I. Jacaranone not only hinders the formation of complex I, but also enhances the assembly of TNFR1 signaling complex II, thereby promoting TNFα-induced apoptosis in cancer cells. Here, TNFRSF1A is linked to cancer.