Absil et al. demonstrated that in the human breast cancer cell line MDA-MB-231, CDCA complexes with the FXR receptor and activates it, thereby initiating the translation of the transcription factor runt-related protein 2 (RUNX2) and the synthesis of bone sialoprotein (BSP) and osteopontin (OPN), which facilitate the progression and development of chest wall tumors [92]. The gene discussed is SPP1; the disease is breast cancer.