Tang’s study revealed that Lusisnthriding, derived from dendrobium, can stimulate the activation of FXR, thereby mitigating hepatic steatosis in mice on a high-fat diet by suppressing the expression of fatty acid synthesis genes, such as Srebp1c, Fas, Scd-1, Dgat1, and Lpin1. This evidence concerns the gene LPIN1 and fatty liver disease.