CDKN2A and head and neck squamous cell carcinoma: In conclusion, QG-MPH quantification of E7 and p16 INK4a mRNA more precisely identifies truly HPV-driven from non-HPV-driven HNSCC, compared to HPV DNA testing alone or with p16 IHC, which reduces misclassification and provides valuable implications for improved prognosis prediction and therapeutic decision-making.