In this study, we describe the application of the novel QuantiGene-Molecular-Profiling-Histology (QG-MPH) assay, which quantifies mRNA expression by multiplexed measurement of 18 individual HPV oncogene E7 plus HPV 16E6, p16 INK4a (referred to herein as p16), and other cancer-associated cellular biomarkers. Here, CDKN2A is linked to cancer.