In patients with nodular goiter (n = 14), significantly lower platelet (PLT) levels were noted (177 × 103/μL [168–211] vs. 181 × 103/μL [134–222], p < 0.001), along with higher chitotriosidase concentrations (341.3 nmol/mL/h [216.5–793.1] vs. 165.3 nmol/mL/h [94.8–670.6], p < 0.001) and higher lysoGb-1 levels (19.3 ng/mL [12.1–40.6] vs. 18.1 ng/mL [11.2–72.2], p < 0.001) compared to patients without nodular goiter. This evidence concerns the gene CHIT1 and nodular goiter.