Similarly, high cholesterol diet increased BBB permeability in LDLR−/− mice, which were more prone to cognitive impairment than wild-type animals [33], and hyperlipidemic mice overexpressing human amyloid precursor protein (APP) showed impaired Aβ clearance associated to derangements in the cerebral vasculature and BBB [34]. This evidence concerns the gene APP and Cognitive impairment.