In middle cerebral artery occlusion/reperfusion-subjected mice and oxygen glucose deprivation/reoxygenation-subjected hippocampal neurons, used to simulate cerebral ischemia-reperfusion injury in vivo and in vitro, the NLRP3/PCSK9 machinery promoted inflammation and pyroptosis, evoking brain damage and neurological deficits [102]. Here, PCSK9 is linked to brain ischemia.