PPARG and obesity due to melanocortin 4 receptor deficiency: This adipocyte differentiation, triggered by the expression of lipogenic genes like CEBP-α and PPARγ, promotes the increase in the depot of adipose tissue and increases the synthesis of inflammatory cytokines related to obesity, such as IL-6, TNF-aα, and IFN-γ, a critical factor in developing degenerative and chronic diseases like obesity and metabolic syndrome.