Proteins of the Apba1/X11/Mint1 family function as adaptors and are able to bind the amyloid precursor protein (App), the precursor of amyloid beta peptide (Abeta); by doing that, they prevent the proteolytic step leading to Abeta production and consequent accumulation in neuritic plaques, a process associated with the aetiogenesis of Alzheimer’s disease (AD) [112]. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.