Likewise, odontoblast progenitor-specific genes (Twist2, Igfbp5, Tnc, Gsc, Bmp4, Msx2, Klf4, Tgfbr2, Fam20a) were also significantly downregulated in incisors of T2DM mice, while mature odontoblast markers did not decrease (Figure 4D, Table 5 right). This evidence concerns the gene IGFBP5 and type 2 diabetes mellitus.