Through a variety of bioinformatics methods, a study has found and identified five differentially expressed genes in vivo that are involved in ferroptosis-related primary osteoporosis in BMSCs, including heat shock protein family A (Hsp70) member 5 (HSPA5), SIRT1, hypoxia inducible factor 1 subunit alpha (HIF1A), mechanistic target of mTOR, and beclin 1 (BECN1). This evidence concerns the gene HIF1A and osteoporosis.