For instance, the upregulation of circEXOC5 exacerbated sepsis-induced acute lung injury (ALI) by stimulating ferroptosis through insulin-like growth factor-2 mRNA-binding proteins 2 (IGF2BP2) recruitment for degrading activating transcription factor 3 (ATF3) mRNA [45]. This evidence concerns the gene IGF2BP2 and acute respiratory distress syndrome.