Davenport and colleagues [86] defined two distinct sepsis response signatures (SRSs) in the transcriptomic profile of adult patients with sepsis (270 patients in the discovery cohort and 114 in the validation cohort), SRS1 and SRS2, based on a set of seven predictive genes of group membership (DYRK2, CCNB1IP1, TDRD9, ZAP70, ARL14EP, MDC1, and ADGRE3) assayed on peripheral blood leukocytes. Here, ADGRE3 is linked to Sepsis.