LRP5 and osteoporosis: Genome-wide association studies (GWAS), leveraging the power of microarray and sequencing technologies, have identified numerous genes linked to osteoporosis, including those coding for extracellular matrix proteins (e.g., COL1A1/2) [9], cell receptors (e.g., VDR and LRP5) [10,11], and key components of signaling pathways such as WNT [12].