In this study, through whole-genome sequencing analyses of a cohort of osteoporotic patients, we identified numerous single-nucleotide polymorphisms (SNPs) that had not been previously associated with osteoporosis in genome-wide association studies (GWAS), leaving their role in osteogenic differentiation largely unknown (e.g., intron variants of RXFP2 gene were found in all osteoporotic patients but not in control individuals (Figure 2B)). Here, RXFP2 is linked to osteoporosis.