Missense mutations in ADRB2, CNR2, FSHR, TSHR, CALCR, and GIPR genes were earlier associated with decreased BMD and osteoporosis in postmenopausal women [26,27,28,29,30,31] as leading to amino acid substitutions and the possible receptor structure and/or function change. The gene discussed is ADRB2; the disease is osteoporosis.