Additionally, CML, DLBCL, FL, MCL and PTCL also have specific genes with multiplicity one and some of them are also recognized to have impact on prognosis and treatment (e.g., SFRP1 for CML [33], NUPR1 for DLBCL [34], HTR3A and IGH for FL [35,36], SOX11 for MCL [37]). The gene discussed is SFRP1; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.