APOE and Alzheimer disease: Age and sex are part of the non-modifiable risk factors that could influence the development of AD, as well as genetic factors; it is known that the inheritance of particular mutations in genes like amyloid precursor protein (APP), presenilin-1 (PSEN-1), presenilin-2 (PSEN-2), and apolipoprotein E (ApoE) are associated with AD [22,23,24].