So, the selected sequences were chosen for two main reasons: (i) biological relevance, since the ability to form G4 structures with a higher number of base pairs (22 bp) allows for the formation of more complex and biologically relevant structures that better resemble those observed in living organisms, particularly in cancer cells; and (ii) therapeutic potential, since G4 structures in oncogene promoters, such as MYC and KRAS, play a critical role in gene regulation, making them important targets for therapeutic intervention. Here, KRAS is linked to cancer.