TNFSF11 and rheumatoid arthritis: For example, it was shown to effectively inhibit Receptor activator of nuclear factor-κB ligand (RANKL) expression by inhibiting the JAK2/STAT3 pathway and upregulating SOCS3 in rheumatoid arthritis fibroblast-like synoviocytes (FLS) stimulated with IL-6/sIL-6R [26].