Some pathways are even independent, such as versican (VCAN)/Extracellular signal-Regulated Kinase (ERK) and poly [ADP-ribose] polymerase 1 (PARP1)/Zinc finger E-box-Binding homeobox 1 (ZEB1) pathways, which promote the proliferation and migration of colorectal cancer cells, regulated directly or indirectly by collagen [79]. This evidence concerns the gene VCAN and colorectal cancer.