IGF1 and glioblastoma: For this reason, its silencing in glioblastoma cells causes a downregulation of genes related to tumor progression and DNA repair mechanisms, including PI3K/AKT, Insulin-like Growth Factor 1(IGF1), Fms-like Tyrosine kinase 3 (FLT3), Platelet-Derived Growth Factor (PDGF), and MAPK [227].