The present study was double-aimed to (i) characterize the polyphenolic composition of two black chokeberry extracts (BChEs) obtained from dried and frozen Aronia fruits and (ii) assess their anti-oxidant effect and the catalase-like scavenger one as being responsible for the vasculo-protective effects in isolated mice aortic rings after incubation with angiotensin 2 (Ang2), lipopolysaccharide (LPS) and high glucose (GLUC) in order to mimic the classic neurohumoral changes (i.e., renin–angiotensin system activation, inflammation and hyperglycemia) commonly found in cardio-metabolic diseases. Here, REN is linked to Hyperglycemia.