In this context, we investigated the expression of the T cell exhaustion markers PD-1, TIM-3, and LAG-3 on intra- and peritumoral TILs as well as the expression of the stroma senescence markers IL-8 and MMP-3 on intra- and peritumoral tumor-associated fibroblasts in a cohort of n = 116 HNSCC patients. Here, MMP3 is linked to head and neck squamous cell carcinoma.