Interestingly, the co-expression of tumor necrosis factor (TNF) superfamily member 14 (LIGHT) in CAR-T cells reconstituted a high immune-infiltrated tumor microenvironment and also improved CCL19 and CCL21 expression by surrounding cells, as shown in an immunodeficient NSG prostatic tumor mouse model [81]. This evidence concerns the gene TNFSF14 and prostate neoplasm.