It balances IL-22’s main function in wound healing and in maintaining tissue homeostasis, it may reduce the tumor-promoting activity of IL-22 in hepatocellular carcinoma and may block IL-22 involvement in liver cirrhosis, chronic inflammation, psoriasis, and arthritis (Dumoutier et al., 2001) (Mühl & Bachmann, 2019) (Zenewicz, 2021) [111,115,116]. Here, IL22 is linked to arthritic joint disease.