We (Volfovitch et al., 2022) [81] and others have reported elevated levels of IL-18 in severe cases of COVID-19, with an emphasis on the levels of free IL-18 and IL-18BP (Nasser et al., 2023) (Peleman et al., 2023) (Korotaeva et al., 2024) (Mehta et al., 2024) [65,82,83,84]. Here, IL18 is linked to COVID-19.