IL18 and autoimmune disease: In Th1-dominated immune responses, IL-18 enhances the activity of NK cells and cytotoxic T cells, e.g., to combat intracellular pathogens, fight cancer cells, and trigger autoimmune diseases (Nakanishi et al., 2001) (Steinman, 2007) (Novick et al., 2013) [14,15,16].