Given its importance, the role of IGFBP3 in glucose metabolism has also been investigated in multiple studies, where Igfbp3 expression was reported to be related to insulin levels in obese patients undergoing sleeve gastrectomy and IGF1 levels in rehabilitating non-small cell lung cancer (NSCLC) patients with exercise interventions [47,48]. Here, IGFBP3 is linked to non-small cell lung carcinoma.