CAMK2G and ischemia: As another signaling pathway, it was reported that RIPK3 activates Ca2+–calmodulin-dependent protein kinase (CaMKII) through the direct binding and phosphorylation of CaMKII at Thr287 when necroptosis is induced in cardiomyocytes with ischemia/reperfusion injury or doxorubicin-induced cardiac damage [18].