However, further increases in the PI3K/Akt signaling pathway through pharmacological treatment and gene knockout such as SFRP4 are beneficial in suppressing cardiac apoptosis in MI models as well, suggesting that the PI3K/Akt signaling pathway is one of the key pathways for apoptosis induction in both MI and MIRI [35,36,37]. This evidence concerns the gene AKT1 and myocardial infarction.