Numerous research studies have indicated that CYP1A1*2C polymorphisms are linked to increased incidence of malignancies of the head and neck, prostate cancer, and esophageal cancer [14,41,42], whilst others showed no association between CYP1A1*2C polymorphisms and gastric cancer and colorectal cancer [43,44]. This evidence concerns the gene CYP1A1 and esophageal cancer.