We found that the frequency of the homozygous mutant CYP1A1 genotype (GG) was significantly higher in Ph-ve patients (23.1%) compared to controls (8%), indicating that individuals carrying it are more susceptible to developing Ph-ve CML (OR = 4.625, 95% CI = 1.181–18.119, p = 0.028). Here, CYP1A1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.