According to another report [147], in which neuritic plaques within the entorhinal cortex were found inversely associated with Bdnf gene expression in the hippocampus, defective BFNF signaling might occur both upstream of the neuropathological hallmarks of AD and downstream of the exacerbation of amyloid plaque load and abnormal tau tangles. The gene discussed is BDNF; the disease is Alzheimer disease.