Similarly, the pharmacological increase in dopaminergic tone, for instance by administration with dopamine D2 and D3 (and serotonin 5-HT1A) receptor partial agonists, such as aripiprazole, can produce relief from depressive symptoms, especially for treatment-resistant depression [152], and cabergoline administration in rats was shown to relieve depression-like behaviors and potentiate BDNF intracellular signaling in the hippocampus [153]. This evidence concerns the gene BDNF and depressive disorder.