INS and myocardial infarction: Similarly to the antiapoptotic effects found in β-cells and glucose-stimulated insulin secretion described after recombinant irisin administration [31], this study [94] demonstrated that irisin can contribute to improving insulin signaling in cardiomyocytes via the activation of the PI3K-Akt pathway, thus providing high benefits in terms of the possible prevention of metabolic alterations, cardiovascular diseases (e.g., myocardial infarction), heart failure, and the general deterioration of cardiac function.