FNDC5 and pancreatitis: In an animal model using L-arginine-induced pancreatitis, it was shown that irisin administration reduced both oxidative stress and ER stress in intestinal cells [43], thus demonstrating the antioxidant potential of irisin as well as its ability to alleviate hepatic injury by increasing mitochondrial biogenesis and upregulating uncoupling protein (UCP) 2 expression [44], which plays a role in ROS reduction and mitochondrial function [45].