Similarly to the antiapoptotic effects found in β-cells and glucose-stimulated insulin secretion described after recombinant irisin administration [31], this study [94] demonstrated that irisin can contribute to improving insulin signaling in cardiomyocytes via the activation of the PI3K-Akt pathway, thus providing high benefits in terms of the possible prevention of metabolic alterations, cardiovascular diseases (e.g., myocardial infarction), heart failure, and the general deterioration of cardiac function. This evidence concerns the gene FNDC5 and heart failure.