The overall stable frequencies of IFN-γ-producing CD4 and CD8 cells and decreasing frequencies of CIK cells were seen, whereas frequencies of iNKT cells slightly increased during Kit M treatment but decreased under chemotherapy, suggesting a slight in vivo production/activation (potentially leukemia-specific) or at least stable frequencies of cells (Figure 5B, P1601). The gene discussed is IFNG; the disease is leukemia.