PAK2 is expected to be substantially activated in ccRCC tumors, according to a comprehensive proteomics investigation conducted by Senturk et al. One study reported that the small GTPases Rac1 and Cdc42 are known to activate PAKs, which are essential for cytoskeletal dynamics, invasion, metastasis, cell death, and proliferation [72]. This evidence concerns the gene PAK2 and nonpapillary renal cell carcinoma.