Given that hyperinflammation significantly contributes to organ injury, and mechanistic studies using adrenal SR-BI-null mice as an adrenal insufficiency model have demonstrated that GC functions control inflammation, and adrenal insufficiency is a risk factor for sepsis, we advocate for a precision medicine approach to guide GC therapy for sepsis—timely and selectively applying GC therapy to patients with adrenal insufficiency, not without. Here, SCARB1 is linked to Adrenal insufficiency.