SCARB1 and Sepsis: SR-BI protects against sepsis through multiple mechanisms (Figure 2): (1) SR-BI protects against NO-induced cytotoxicity; (2) SR-BI mediates hepatic LPS clearance and cholesterol metabolism; (3) macrophage SR-BI inhibits LPS-induced inflammatory signaling; (4) adrenal SR-BI mediates the uptake of cholesterol from HDL for iGC synthesis, which controls the systemic inflammatory response.