Moreover, Chi3l1 is associated with homeostasis model assessment of insulin resistance (HOMA-IR) (R = 0.604, p = 0.029), fasting insulin levels (R = 0.622, p = 0.023), and monocyte chemoattractant protein-1 (MCP-1) (R = 0.805, p = 0.001), indicating its potential roles in the development of IR, T2DM, and even cardiovascular mortality in obese patients [236]. This evidence concerns the gene CCL2 and type 2 diabetes mellitus.