CHI3L1 and Hepatic fibrosis: Chi3l1 has diagnostic value for liver fibrosis diseases of different backgrounds, including metabolic-associated diseases (e.g., nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatosis disease (NASH), and alcoholic liver disease (ALD)) and infection-associated diseases (e.g., hepatitis B virus (HBV)-related and hepatitis C virus (HCV)-related liver fibrosis) [75].