Oleanolic acid (OA) administration partially decreases the level of Chi3l1 from 14.60 ± 1.00 ng/mL to 10.60 ± 0.90 ng/mL and alleviates renal damage-related inflammatory and oxidative profiles in diabetic rats, indicating its potential application in diabetes and diabetic nephropathy [305]. The gene discussed is CHI3L1; the disease is diabetes mellitus.