CHI3L1 and cardiovascular disorder: With respect to circulatory system-related diseases, the progression of cardiovascular disease (CVD) can be prevented by vitamin D-mediated Chi3l1 suppression, and this suppression may be achieved by inhibiting IL-6, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) [299].