CHI3L1 and chronic periodontitis: In recent years, Chi3l1 in serum and gingival crevicular fluid has been identified as a novel biomarker for diagnosing and assessing the severity of periodontitis, whereas nonsurgical periodontal therapy and Moringa oleifera can effectively decrease Chi3l1 levels in chronic periodontitis patients or a periodontitis rat model [101,102,103].