Upregulated Chi3l1 can act as a diagnostic and prognostic biomarker for placenta accreta spectrum disorders (PASs), and a mechanistic study further revealed that Chi3l1 significantly promotes the proliferation and invasion of HTR-8/SVneo cells via the activation of Akt/MMP9 signaling in this disease (Figure 2) [287,288]. The gene discussed is CHI3L1; the disease is Loss of consciousness.