Many of these interactions have been experimentally validated, such as CREB3L1 driving fibroblast differentiation in systemic sclerosis [29], HOXA9 overexpression in dermal fibroblasts [30], and GATA2 playing a key regulatory role in bovine rumen epithelial cells [31], which further supports the credibility of our predictions. Here, CREB3L1 is linked to systemic sclerosis.