RYR2 and catecholaminergic polymorphic ventricular tachycardia: Nevertheless, dantrolene, a muscle relaxant that has shown preventive behavior toward CPVT in a CPVT mutant knock-in mouse model [115], has been identified as facilitating the affinity of calmodulin, a calcium-sensitive protein that inhibits RyR2 activity, to RyR2 in mild hypertensive HFpEF rats, hence attenuating Ca release [111].