Our searches were not limited by date restrictions, were free texts, and included the following keywords: “heart failure”, “heart failure with preserved ejection fraction”, “diastolic dysfunction”, “sudden cardiac death”, “obesity”, “lipid mediators”, “leukotrienes”, “ventricular arrhythmias”, “dyslipidemia”, “cardiac calcium channel”, “cardiac potassium channel”, “cardiac sodium channel”, “Ca handling proteins”, “SERCA2a”, “RyR2”, “phospholamban”, “pro-inflammatory cytokines”, “interleukin signaling”, “leukotrienes B4 signaling”, and “cBIN1”. The gene discussed is PLN; the disease is obesity due to melanocortin 4 receptor deficiency.