Qian et al. identified that inhibition of TLR2 by C29 (a TLR2 inhibitor) or TLR2-knock-out high-fat-diet-fed mice successfully reversed the elevated creatine kinase MB (CK-MB) and cytokine (IL-6, IL-1β, and TNF-α) levels, and it attenuated cardiac hypertrophy and myocardial fibrosis, confirming the role of TLR2 in obesity-mediated cardiomyopathy [184]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.