Figure 2 illustrates known oncogenic pathways affected by mutations, showcasing myeloma-typical pathways pivotal for MM pathogenesis, such as MAPK [25,26,27], NOTCH [28], HIPPO [29], WNT [30], IP3K [31], NRF2 [32], TGF b, MYC, and TP53 [33]. While some pathways were found to be affected with high frequency, especially RTK-RAS and NOTCH pathways (see Figure 2A), others were only found in two samples (NRF2). Here, ITPKB is linked to plasma cell myeloma.