While the hypomodification of tRNAphe by the silencing of TYW2 leads to a ribosome frameshift and poorer outcome in colorectal cancer patients [45], the role of TYW1 mutations on tRNA modification, the resulting translational changes, its implications on tumorigenesis, and its role as a possible therapeutic target in MM need to be studied further. The gene discussed is TYW2; the disease is colorectal cancer.