In a previous work [21], we investigated the effects of the mutations D75N and P161S in cMyBP-C associated with hypertrophic cardiomyopathy on actin-myosin interactions at the molecular level; we found that they disrupt calcium regulation and, in addition, that the mutation D75N affects myosin function. The gene discussed is MYH14; the disease is hypertrophic cardiomyopathy.