PPARGC1A and essential thrombocythemia: The association of ET with variants in the PTGFRN (rs1127215), PPARGC1A (rs17590046), MIR924HG (rs1945016), LOC105379011 (rs28562175), and LINC00323 (rs9980363) genes have been found in a recent GWAS and meta-analysis involving 7177 ET patients and 475,877 controls [12].