Similarly, a study by Frank et al. (2024) found that FXYD2 was one of four main genes involved in the progression of cholangiocarcinoma promoting cell proliferation and migration in cholangiocarcinoma, since the overexpression of FXYD2 was implicated in dysplasia and the poor prognosis of patients from which organoids excised from gallbladder epithelial cells carcinoma were analyzed [272]. Here, FXYD2 is linked to cholangiocarcinoma.