This study aims to investigate the modulatory effects of IFN-γ and a proinflammatory cytokine mix (5MIX: IL-1α, IL-17A, IL-22, OsM, and TNF-α) on keratinocyte antigen-presenting capacities and their interactions with CD4+ lymphocytes, with a specific focus on their role in psoriasis pathogenesis. This evidence concerns the gene IL22 and psoriasis.